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The identification of methylation signatures, such as those distinguishing IDH mutant and IDH wild-type GBMs, provides a framework for personalized treatment strategies

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fEPSPs were recorded and filtered (low pass at 2 kHz) with a MultiClamp 700B amplifier (Axon Instruments, Union City, CA, USA), digitized at 10 kHz with an A/D converter (Digidata 1550 A, Axon Instruments), and analyzed with Pclamp10.7 and Clampfit10.7 software (Molecular Devices, San Jose, CA, USA)